Prognostic factors for early mortality in patients with septic shock at the National Hospital for Tropical Diseases from 2017-2022

ABSTRACT

Objectives: This study aimed to analyze early mortality prognostic factors in patients with septic shock at the National Hospital for Tropical Diseases during the period from 2017 to 2022.

Participants and Methods: A cross-sectional study was conducted on 260 patients aged ≥ 18 years diagnosed with septic shock after hospital admission. Univariate and multivariate logistic regression analyses were performed to identify clinical and laboratory factors associated with early mortality in septic shock patients.

Results: Early mortality within 3 days of hospital admission accounted for 30.4%, while late mortality after 3 days of admission was 34.6%. Several clinical factors, such as age ≥ 50 years (OR: 5.5; 95%CI: 1.7-17.8), onset ≤ 7 days (OR: 4.1; 95%CI: 1.4-12.0), respiratory organ failure at admission (OR: 7.5; 95%CI: 2.5-22.0), and hepatobiliary organ failure at admission (OR: 12.9; 95%CI: 3.7-44.7), as well as laboratory factors at admission, including white blood cell count < 4 G/L (OR: 5.8; 95%CI: 1.5-22.9), serum creatinine ≥120 µmol/L (OR: 4.7; 95%CI: 1.8-12.4), serum albumin ≤ 30 g/L (OR: 2.6; 95%CI: 1.1-5.9), and blood lactate > 4 mmol/L (OR: 2.9; 95%CI: 1.0-8.3), were found to be independent predictors of early mortality in patients with septic shock.

Conclusion: This study identified several clinical and laboratory factors as independent predictors of early mortality in patients with septic shock, highlighting the importance of early recognition and management of high-risk patients to improve outcomes.

Keywords: Prognostic factors, mortality, septic shock, early mortality

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