A narrative review of clinical management of Clostridium difficile in hospital setting

 https://doi.org/10.52322/jocmbmh.07.en.01

ABSTRACT

Clostridium difficile is a Gram-positive, strictly anaerobic, spore-forming bacteria that produces a range of presentation from mild, self-limiting diarrhea to life-threatening fulminant colitis, which can end in death. In recent years, Clostridium difficile has become a serious healthcare-associated infection (HAI) worldwide, posing a considerable burden on health care systems. The most major modifiable risk factor for C. difficile remains antibiotic usage. There is presently no gold standard diagnostic test or testing methodology available. The most effective initial treatment is to discontinue the inciting antibiotic agent as soon as possible, followed by the administration of an antibiotic that is less frequently implicated in antibiotic-associated C. difficile infection. Despite advancements in diagnostic techniques and treatment choices over the past decade, the burden of C. difficile continues to pose major problems. This review aims to update the clinical management of C. difficile infection in healthcare setting.

Keywords: Clostridium difficile, epidemiology, diagnose, treatment, management, hospital setting

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