Clinical manifestations, laboratory findings, antimicrobial susceptibility and outcomes of Enterococcus blood stream infection at Bach Mai Hospital and National Hospital for Tropical Diseases

 https://doi.org/10.52322/jocmbmh.07.en.12

ABSTRACT

Objectives: To describe the clinical features and laboratory characteristics of Enterococcus blood stream infections (BSI) at Bach Mai Hospital and the National Hospital for Tropical Diseases, as well as assess the antibiotic susceptibility and treatment outcomes from 2015 to 2019.

Material and Methods: We conducted a cross-sectional study was carried out on 48 patients diagnosed with Enterococcus bacteremia (19 patients at the Central Hospital for Tropical Diseases, Bach Mai Hospital from January 2015 to July 2019 and 29 patients at National Hospital for Tropical Diseases from August 2018 to July 2019). 

Results: The two common pathogenic species of Enterococcus BSI were E. faecalis and E. faecium, with E. faecalis accounted for the highest proportion (47.9%). Fever was the most common symptom with 91.7%. WBC, CRP, CRP-hs, and PCT increased on admission and 20.8% had infective endocarditis. The rate of septic shock was 20.8% of enrolled patients. Among 48 isolates of Enterococcus, antibiotic resistance rates were 40.4% with penicillin, 39.6% with ampicillin, 35.9% with piperacillin, 36.6% with unasyl, 50% with gentamycin, 4.2% with vancomycin, and no bacteria strains resistant to linezolid or teicoplanin. The mortality rate was 16.7%. After 3 days of treatment, the white blood cell count, procalcitonin, and CRP-hs has been decreased statistically.

Conclusion: This is the first study has been conducted among patients with Enterococcus BSI at two largest infectious centers in the northern. The findings might be useful for improving the diagnose and treatment for Enterococcus in Vietnam. 

Keywords: Blood stream infection, sepsis, Enterococcus, Vietnam

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