Lower mortality rate of COVID-19 vaccinated patients admitted to a large intensive care center during the outbreak caused by SARS-CoV-2 Delta variant in Vietnam

  • Mã bài báo : 11.EN.13
  • Ngày xuất bản : 30/11/2023
  • Số trang : 118-126
  • Tác giả : Do Ngoc Son
  • Lượt xem : ( 125 )

Danh sách tác giả (*)

  • Do Ngoc Son 1 - Center for Emergency Medicine, Bach Mai Hospital
  • Nguyen Quoc Thai - Center for Tropical Diseases, Bach Mai Hospital
  • Nong Minh Vuong - Institute for Health Sciences, Bach Mai Hospital
  • Luong Quoc Chinh - Center for Emergency Medicine, Bach Mai Hospital
  • Huynh Xuan Nghiem - Hung Vuong Hospital
  • Doan Thu Tra - Center for Tropical Diseases, Bach Mai Hospital
  • Do Van Thanh - Center for Tropical Diseases, Bach Mai Hospital
  • Vu Van Giap - Department of Internal Medicine, Hanoi Medical University
  • Dao Xuan Co - Bach Mai Hospital
  • Do Duy Cuong - School of Medicine and Pharmacy, Vietnam National University Hanoi

https://doi.org/10.52322/jocmbmh.11.en.13

ABSTRACT

Introduction: Vaccinated critically ill COVID-19 patients, even with only the rst dose, showed better outcomes than non- vaccinated individuals during the Delta variant-driven outbreak in Vietnam. In developing countries with limited supply, mass immunization using any accessible type of vaccine are an eective strategy to reduce mortality and burden on health systems.

Objectives: To determine the association between COVID-19 vaccination status and mortality among hospitalized positive patients required intensive care unit (ICU) during the Delta variant-driven wave of COVID-19 in Vietnam

Participants and Methods: We conducted a retrospective observation study among 504 critically ill COVID-19 cases enrolled to ICUs of ICC, BMH from August to September 2021. Kaplan-Meier survival analysis was used to compare 28-day in-hospital mortality between groups. Cox proportional hazards regression adjusted for gender, age, comorbidities, and vital signs at baseline were used to determine the association between vaccination status and mortality outcome among patients. The secondary outcome was the proportion of patients required endotracheal intubation and invasive ventilation, and length of ICU stays.

Results: Out of 504 critically ill COVID-19 patients, 117 (23.2%) were vaccinated with at least one dose. Vaccinated patients were younger (median 57 vs 61 years, p<0.001) and had fewer comorbidities (36.5% vs 63.5%, p<0.001) compared to unvaccinated patients. Vaccinated patients also required less respiratory support and had lower 28-day mortality (31.6% vs 58.4%, p<0.001). In adjusted analysis, vaccination was associated with a 26% reduction in mortality risk (aHR 0.74, 95% CI 0.57-0.96, p=0.036).

Conclusions:  Partial COVID-19 vaccination was associated with signicantly reduced risk of death among critically ill patients admitted to the ICU during the Delta variant surge in Vietnam. Rapidly achieving high rst dose vaccine coverage, even with constraints on optimal vaccine supplies, appeared eective at decreasing COVID-19 mortality and healthcare burden. These real-world data support that vaccination with available options should be urgently prioritized globally to save lives during the pandemic.

Keywords: COVID-19, SARS-CoV-2, Delta variant, vaccines, severe and critical, non-pharmaceutical interventions, Asia, Vietnam

  • DOI : 10.52322/jocmbmh.11.en.13
  • Chủ đề : COVID-19
  • Loại bài báo : Original Research
  • Chuyên nghành : Clinical Medicine

File toàn văn

Chưa có mã code, vui lòng liên hệ để nhận mã theo số điện thoại : 0947040855 - Email : jocm@bachmai.edu.vn

  • Thông tin liên hệ : Do Duy Cuong
  • Email : doduy.cuong@bachmai.edu.vn
  • Địa chỉ : School of Medicine and Pharmacy, Vietnam National University Hanoi

Bài báo liên quan

Nhà tài trợ và đối tác